| ncRNA name | ILK siRNA |
| ncRNA Category | siRNA |
| Disease name | retinoblastoma (RB) |
| Species | Homo sapiens |
| Tissues/Cell_line | human RB cell line Y79 |
| Methods | immunohistochemistry, siRNA transfection, RT-PCR, qPCR, Western blot, CCK-8 assay, Annexin V-FiTC/ proPIdium iodide (PI) immunofluorescence, flow cytometry |
| Expression pattern | associated |
| Functional description | Specific siRNA targeting ILK significantly silenced ILK expression in Y79 retinoblastoma cells. This was accompanied by decreased cell proliferation and enhanced apoptosis. The phosphorylation status of JNK and c-Jun was constitutively activated by ILK siRNA (P < 0.01), and JNK inhibitor simultaneously reversed the effects on cell proliferation and apoptosis induced by ILK siRNA. |
| PubMed ID | 21234586 |
| Year | 2011 |
| Title | c-Jun N-terminal kinase is involved in the regulation of proliferation and apoptosis by integrin-linked kinase in human retinoblastoma cells. |
| Drug-related ncRNA | NO |
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